FRA® LBB is the FRA® C line's combination for optimal gut enhancement as well as for reducing the pressure of gram positive/negative bacteria. Absorption of nutrients will be strongly improved thanks to the  the highly developed intestinal tract. FRA® LBB contains glycerides of butyric, propionic and lauric acid. While lauric acid has a very high melting point, the FRA® LBB is only available in dry form. Nevertheless the product is not pH dependent, odorless, heat stable up to 160° C and non corrosive. Because of the covalent bond FRA® LBB allows the most superior handling.

1-MONO GLYCERIDES OF PROPIONIC ACID AND 1-MONO GLYCERIDES OF BUTYRIC ACID 

Via esterification a fatty acid can be linked to glycerol leading to the forming of a glyceride like 1-monopropionin/1-monobutyrin.  These 1-monoglycerides of propionic acid and butyric acid have polar properties, hence the 1-monopropionin and the 1-monobutyrin are capable of passing the hydrophilic membrane of important pathogenic bacteria, invading the bacteria cell and eliminating it. 

1-monoglycerides of organic acids are up to 30 times more effective against bacteria than just the pure organic acid. Thanks to solubility in water, you immediately see an antibacterial effect in drinking water, feed, mouth and stomach/crop. Besides the strong efficacy  against pathogens, the new molecules like FRA® AC 34 also provide a fungal inhibition similar to propionic acid salts and thus leads to a reduction of the additional costs for preservation of the feed.

These  1-monoglycerides can be used in all farm animal species and there are no negative effects on feed intake, even at high dose levels. The FRA® C-line can be applied for both curative  and preventive purposes against bacteria such as Salmonella, Clostridia, E-Coli, Lawsonia, Colitis, etc.

Many trial results have shown that the glycerides of butyric acid have a very positive influence on the intestinal health of an animal: a better digestibility, a better feed conversion ratio, a reduced mortality rate and a reduction of medication use.

Last but not least glycerides of butyric acid differ from other forms of butyric acid due to the fact that it isthey are odorless which has great advantages in handling, storage and processing.

1- MONO GLYCERIDES OF LAURIC ACID 

1-Monolaurin is a monoglyceride of lauric acid, naturally occurring in mother’s milk and a derivative from coconut oil. The antiviral, antibacterial and antifungal properties of lauric acid and 1-monolaurin have been recognized for nearly three decades by only a small number of researchers: their work, however, has resulted in 100 or more scientific publications and numerous patents. 

In 1968 Prof. Dr. Jon J. Kabara first patented certain fatty acids and its derivatives, e.g. monoglycerides, which can have adverse effects on various microorganisms. 1-Monolaurin, nontoxic and approved as a direct food additive by the FDA and therefore safe for animal nutrition, adversely affects bacteria, yeast, fungi, protozoa and fat enveloped viruses. 

Fatty acid monoglycerides produce their killing/inactivating effects by several modes of action. 

An assumable mechanism is the interruption of the plasma membrane lipid bilayer of the bacterial cell or viral envelope. What happens is that the 1-monolaurin fluidizes the structure in the fat envelope of the virus, causing the disintegration of the membrane therefore preventing it from attaching and entering host cells, making infection and replication impossible. Another effect in viruses is due to the interference of 1-monolaurin with virus assembly and viral maturation.

DI- AND TRIGLYCERIDES OF BUTYRIC ACID 

Di- and tributyrin are non-polar molecules consisting of butyric acid and glycerol. Free butyric acid, butyric salts and coated butyric acid only have antibacterial effect at low PH-values due to its dissociated form at high pH-values. Whereas di- and tributyrin work further in the entire intestinal tract free butyric acid and butyric salts do not. Coated butyric acid reaches the small intestines however due to high pH-values it will have no antibacterial effect. The butyric acid in the di- and tributyrin is released further in the entire intestinal tract by endogenous lipase produced by the pancreas and acts as an energy source for the epithelial cells. 1-Monobutyrin works in the stomach or crop and gizzard and will be right after the stomach taken up into the bloodstream. After the dibutyrin is split off by endogenous lipase 1-monobutyrin remains. This remaining 1-monobutyrin will then be taken up into the bloodstream through the gut wall and keep its  strong anti-bacterial properties.